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Development of a Scalable Synthesis of Casdatifan (AB521), a Potent, Selective, Clinical-Stage Inhibitor of HIF-2α

Clayton Hardman,Artur K. Mailyan,Guillaume Mata,Joel W. Beatty,Samuel L. Drew,Jeremy Fournier,Jaroslaw Kalisiak,Brandon R. Rosen, Matthew Epplin,Balint Gal,Kai Yu,Zhang Wang, Karl Haelsig,Anh Tran,Manmohan R. Leleti,Jay P. Powers,Kenneth V. Lawson

ORGANIC PROCESS RESEARCH & DEVELOPMENT（2025）

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