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Synthesis, Impurity Profiling, Simultaneous NP-HPTLC Method Development, Molecular Modelling Study and EGFR Tyrosine Kinase Inhibitory Profile: an Integrated Approach to Characterize Desethynyl Erlotinib Process Impurity

Kunal Bhadane, Bhatu Patil, Sampath Chinnam,Biswajit Das,Chandragouda Patil, Chandrakant Gawli,Iqrar Ahmad, Amit Shimpi, Yogesh Agrawal, Amod Patil,Atul Shirkhedkar,Nishant Rai, Mahesh Palkar,Siddique Akber Ansari,Irfan Aamer Ansari,Chanakya Nath Kundu,Harun Patel

ANALYTICAL CHEMISTRY LETTERS（2025）

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Key words
Erlotinib,Desethynyl Erlotinib impurity,High Performance Thin Layer Chromatography,Wild Type EGFR Tyrosine Kinase,Docking
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