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Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers.

James Cregg, Anne V Edwards, Stephanie Chang,Bianca J Lee,John E Knox,Aidan C A Tomlinson,Abby Marquez, Yang Liu, Rebecca Freilich, Naing Aay,Yingyun Wang, Lingyan Jiang, Jingjing Jiang,Zhican Wang, Michael Flagella,David Wildes, Jacqueline A M Smith,Mallika Singh,Zhengping Wang,Adrian L Gill,Elena S Koltun

Journal of medicinal chemistry(2025)

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