Rare MTNR1B Variants Causing Diminished MT2 Signalling Associate with Elevated HbA1c Levels but Not with Type 2 Diabetes

Kimmie V. Sørensen,Johanne M. Justesen,Lars Ängquist,Jette Bork-Jensen,Bolette Hartmann, Niklas R. Jørgensen,Jørgen Rungby, Henrik T. Sørensen,Allan Vaag,Jens S. Nielsen, Jens J. Holst,Oluf Pedersen,Allan Linneberg,Torben Hansen,Niels Grarup

Diabetologia（2025）

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Key words

Genetic association study,HbA1c,Melatonin,Melatonin receptor type 2,MT2,MTNR1B,Recall-by-genotype investigation,rs10830963,Type 2 diabetes,Variants impairing receptor function

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