A Multicentre Randomised Controlled Trial Assessing the Efficacy of Antimicrobial Prophylaxis for Extracorporeal Shock Wave Lithotripsy in Reducing Urinary Tract Infection (APPEAL): Statistical Analysis Plan and Methodology Philippe D. Violette , Farhad Tondro Anamag , Sameer Parpia , Sara V. Tornberg , Arto Mikkola , Sakineh Hajebrahimi , Saana Horstia , Borna Tadayon Najafabadi , Jani Ruotsalainen , Pramila Gaudel , Le Mai Tu , Thomas Tailly , Farzin Soleimanzadeh , Hanieh Salehi Pourmehr , Mari Saalasti , Patrick O. Richard , Hassan Razvi , Negar Pourjamal , Stephen E. Pautler , Sanna Myrskysalo , Andrei O. Morozov , Mohsen Mohammadrahimi , Murilo de Almeida Luz , Samuel Lagabrielle , Pauliina Kuutti , Tuomas P. Kilpelainen , Petrus Jarvinen , Alireza Farshi Haghro , Salam A. Hussain , Agus Rizal A. H. Hamid , Dmitry Gorelov , Nariman Gadzhiev , John Denstedt , Kathrin Bausch , Raed A. Azhar , Moza Al Hail , Nourieh D. Akbari , Mohamed A. AbdElAziz , Mohamed Abdelkareem , Gordon H. Guyatt , Kari A. O. Tikkinen medrxiv（2025）
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