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    • Active Microgel Particle Swarms for Intrabronchial Targeted Delivery.

    Hui Chen,Junhui Law, Yibin Wang, Ziheng Chen,Xingzhou Du, Kaiwen Fang,Zhe Wang, Feng Duan,Yu Sun,Jiangfan Yu

    Science advances（2025）

    School of Science and Engineering | Department of Mechanical and Industrial Engineering

    Cited 0|Views7
    Abstract
    Intrabronchial delivery of therapeutic agents is critical to the treatment of respiratory diseases. Targeted delivery is demanded because of the off-target accumulation of drugs in normal lung tissues caused by inhalation and the limited motion dexterity of clinical bronchoscopes in tortuous bronchial trees. Herein, we developed microrobotic swarms consisting of magnetic hydrogel microparticles to achieve intrabronchial targeted delivery. Under programmed magnetic fields, the microgel particle swarms performed controllable locomotion and adaptative structure reconfiguration in tortuous and air-filled environments. The swarms were further integrated with imaging contrast agents for precise tracking under x-ray fluoroscopy and computed tomography imaging. Magnetic navigation of the swarms in an ex vivo lung phantom and in vivo delivery into deep branches of the bronchial trees were achieved. The on-demand reconfiguration of swarms for avoiding the microgel particles from entering nontarget bronchi and the precise delivery into tilted bronchi through climbing motion were validated.
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    Chat Paper
    【要点】：本研究开发了一种由磁性水凝胶微颗粒组成的微机器人群体，用于实现支气管内药物的精确靶向递送。
    

    【方法】：利用编程磁场控制微凝胶颗粒群体的运动和自适应结构重构，以适应曲折且充满空气的支气管环境。
    

    【实验】：通过在体外肺模型中的导航和在体支气管深部的递送实验，验证了微凝胶颗粒群体在避开非目标支气管和精确递送到倾斜支气管中的能力，使用的数据集为体外肺模型和体内支气管模型。