Effect of Home-Based Transcranial Direct Current Stimulation (tdcs) on Cognitive Functioning in Bipolar Depression: an Open-Label, Single-Arm Acceptability and Feasibility Study

Hakimeh Rezaei,Rachel D. Woodham,Ali-Reza Ghazi-Noori,Philipp Ritter,Elvira Bramon,Michael Bauer,Allan H. Young,Cynthia H. Y. Fu

International Journal of Behavioral Medicine（2025）SCI 4区

Technische Universität Dresden | University of East London | University College London | King’s College London

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Abstract

Bipolar depression is commonly accompanied by cognitive impairments. Transcranial direct current stimulation (tDCS) is emerging as a novel non-invasive treatment for bipolar depression. Given the portability and safety of tDCS, we developed a home-based protocol with real-time supervision. Our aim was to assess the cognitive effects of a course of tDCS treatment in bipolar depression. 44 participants (31 women, mean age 47.27 years, SD 12.89) with bipolar depression of at least a moderate severity received 21 sessions of home-based tDCS over 6 weeks in an open-label design. The stimulation protocol involved 2 mA in a bilateral frontal montage (F3 anode, F4 cathode) for 30 min per session. Cognitive assessments were conducted at baseline and after the course of treatment: Rey Auditory Verbal Learning Test (RAVLT) to assess verbal learning and memory and Symbol Digit Modalities Test (SDMT) to assess psychomotor processing speed and visuospatial attention. 93.18

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Key words

Transcranial direct current stimulation,Bipolar depression,Cognitive impairment,Home-based treatment,Neuropsychological tests,RAVLT,SDMT

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【要点】：本研究探索了家庭式经颅直流电刺激（tDCS）对双相抑郁症患者认知功能的影响，证明了该治疗方式在改善认知功能方面的可行性和可接受性。

【方法】：研究采用开放标签、单臂设计，对44名中度以上双相抑郁症患者实施了21次家庭式tDCS治疗。

【实验】：实验使用Rey Auditory Verbal Learning Test（RAVLT）和Symbol Digit Modalities Test（SDMT）在基线和治疗结束后对患者进行认知评估，结果显示认知功能有所改善。

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