Assessing the Relationship Between MR-Based Functional Dose Metrics and Post-Stereotactic Body Radiation Therapy Albumin-Bilirubin Change.
International journal of radiation oncology, biology, physics（2025）
Department of Radiation Oncology
Abstract
PURPOSE:This study aimed to identify predictors of global liver function change measured by albumin-bilirubin (ALBI) score following stereotactic body radiation therapy (SBRT) in patients with hepatocellular carcinoma (HCC). By integrating gadoxetic acid-enhanced magnetic resonance imaging (MRI) uptake and dosimetric data, the goal was to develop functional-based treatment-planning strategies that preserve hepatic function. METHODS AND MATERIALS:Twenty-five patients with HCC enrolled on an institutional review board-approved adaptive SBRT trial had liver dynamic gadoxetic acid-enhanced MRI and blood sample collections before and 1 month after SBRT. Gadoxetic acid uptake rate (k1) maps were quantified for regional hepatic function and coregistered to both 2-Gy equivalent dose and physical dose distributions. Mean or integral-based metrics, dose-volume or function-volume histogram metrics, and function-dose-volume histogram metrics were calculated. These metrics were correlated with percentage ALBI score changes by Spearman rank correlation with Bonferroni correction. RESULTS:We found that the greater the sparing of liver with high-hepatic function (k1 intensity), the less the decline of ALBI score post-RT. The threshold for preserving global hepatic function was 10 % of the maximum k1 intensity and 5 Gy EQD2. The integration of regional function (k1) and dosimetric data improved the ability to predict ALBI score changes compared with dosimetric or functional data alone. CONCLUSIONS:Combining regional liver function metrics from gadoxetic acid-enhanced MRI with radiation dose provides a robust model for predicting ALBI score changes following SBRT. These findings suggest that there is a potential for functional-based treatment planning to better preserve liver function in patients with HCC undergoing SBRT. Future studies are needed to externally validate these findings.
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