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Avidity and Variable Domain Spacing Strongly Influence the Therapeutic Potency of Bispecific Antibodies Against Crimean-Congo Hemorrhagic Fever Virus

Albert Wang, Stephanie R Monticelli,Ariel S Wirchnianski,Dafna M Abelson,Ana I Kuehne,Russell R Bakken, Marissa Middlecamp, Michael Weingart,Olivia Vergnolle,Zachary A Bornholdt,Crystal L Moyer, Jacob L Berrigan, Brandyn R West,J Maximilian Fels,Larry Zeitlin,Andrew S Herbert,Kartik Chandran, Chowdhury Raihan Bikash,Jonathan R Lai

mBio（2025）

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Key words
Crimean-Congo hemorrhagic fever virus,monoclonal antibody,bispecific antibody,immunotherapy
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