Scaffold Hopping-Based Structural Modification of Tranilast Led to the Identification of HNW005 As a Promising NLRP3 Inflammasome and URAT1 Dual Inhibitor for the Treatment of Gouty Arthritis.

Ming Sun, Fengwei Lin, Chenchen Yue, Zijie Wei, Chang Liu,Dan Liu, Xing Chen,Qi Li, Ziyuan Liu,Jihong Han, Zichen Cui, Qing Mao,Xinyu Li,Peng Zhang,Bing Zhang, Xuefeng Fu, Han Wang,Yanhua Mou,Shaojie Wang

European journal of medicinal chemistry（2025）

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