CDH17-targeting CAR-NK Cells Synergize with CD47 Blockade for Potent Suppression of Gastrointestinal Cancers

Liuhai Zheng, Youbing Ding, Xiaolong Xu, Huifang Wang, Guangwei Shi,Yang Li,Yuanqiao He, Yue Gong, Xiaodong Zhang, Jinxi Wei, Zhiyu Dong, Jiexuan Li,Shanchao Zhao,Rui Hou, Wei Zhang,Jigang Wang,Zhijie Li

Acta pharmaceutica Sinica B（2025）

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Key words

Gastrointestinal cancers,CDH17,Nanobody,CAR-NK,CD47–SIRPα checkpoint,CV1

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