High KYNU Expression is Associated with Poor Prognosis, KEAP1/STK11 Mutations, and Immunosuppressive Metabolism in Patient-Derived but Not Murine Lung Adenocarcinomas

Ling Cai, Thomas J Rogers, Reza Mousavi Jafarabad, Hieu Vu,Chendong Yang, Nicole Novaresi,Ana Galán-Cobo,Luc Girard,Edwin J Ostrin,Johannes F Fahrmann,Jiyeon Kim,John V Heymach,Kathryn A O'Donnell,Guanghua Xiao,Yang Xie, Ralph J DeBerardinis,John D Minna

Cancers（2025）

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Key words

lung adenocarcinoma,kynurenine pathway,tryptophan catabolism,NAD metabolism,kynureninase,KYNU,immune suppression,KEAP1,STK11,prognostic biomarker,mouse model limitations

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