Chromothripsis-associated Chromosome 21 Amplification Orchestrates Transformation to Blast-Phase MPN Through Targetable Overexpression of DYRK1A.
Charlotte K Brierley,Bon Ham Yip,Giulia Orlando,Jeremy Wen, Sean Wen, Harsh Goyal, Max Levine, G Maria Jakobsdottir,Avraam Tapinos,Alex J Cornish, Antonio Rodriguez-Romera, Alba Rodriguez-Meira, Matthew Bashton,Angela Hamblin, Sally Ann Clark, Joseph C Hamley, Olivia Fox, Madalina Giurgiu, Jennifer O'Sullivan,Lauren Murphy, Assunta Adamo, Aude Anais Olijnik,Anitria Cotton, Emily Hendrix,Shilpa Narina,Shondra M Pruett-Miller,Amir Enshaei,Claire Harrison, Mark Drummond,Steven Knapper,Ayalew Tefferi,Iléana Antony-Debré,James Davies,Anton G Henssen,Supat Thongjuea, David C Wedge, Stefan N Constantinescu,Elli Papaemmanuil,Bethan Psaila,John D Crispino, Adam J Mead Nature genetics（2025）
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