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Exploring Experimental Models of Colorectal Cancer: A Critical Appraisal from 2D Cell Systems to Organoids, Humanized Mouse Avatars, Organ-on-Chip, CRISPR Engineering, and AI-Driven Platforms—Challenges and Opportunities for Translational Precision Oncology

Ahad Al-Kabani, Bintul Huda, Jewel Haddad, Maryam Yousuf, Farida Bhurka, Faika Ajaz, Rajashree Patnaik, Shirin Jannati,Yajnavalka Banerjee

Cancers(2025)

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colorectal cancer models,in vivo CRC models,humanized mouse models,tumor-on-a-chip,artificial intelligence,patient-derived xenografts,CRC translational research,organoid models,preclinical CRC modeling,experimental oncology
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