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Neurology and clinical neuroscience Journal

Papers
The patient is an 80‐year‐old man. At the age of 76, he presented with acute onset of severe orthostatic hypotension and diarrhea. Anti‐ganglionic acetylcholine receptor (anti‐gAChR) antibodies were positive, and prednisolone was effective. He was diagnosed with autoimmune autono...
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An 87-year-old female presented altered mental status and left hemiparesis. A cerebral angiogram showed abrupt cutoff of the right internal carotid artery. Mechanical thrombectomy was performed. Postoperative transthoracic echocardiography revealed a free-floating ball thrombus (...
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Previously, we identified a brain‐type creatine kinase antibody to be associated with paraneoplastic cerebellar degeneration using a proteomic approach. Immunohistochemistry showed that this antibody reacted with both mouse cerebellar neurons and bladder cancer tissues. Furthermo...
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We report the first autopsy case of MM1-type sporadic Creutzfeldt-Jakob disease (sCJD) who survived 80 months after long-term artificial ventilatory support. The cerebral cortex and white matter exhibited severe atrophy, sparing the hippocampus. The prion protein aggregates of 10...
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Patients with neuronal intranuclear inclusion disease (NIID) can present with encephalitis‐like symptoms such as recurrent paroxysmal fever and unconsciousness. To date, no specific triggers for these symptoms have been reported. In our case, an 78‐year‐old woman became unconscio...
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Anti‐glutamic acid decarboxylase (GAD) antibody (Ab)‐associated autoimmune cerebellar ataxia (CA) is a rare neurological disorder, and a standardized therapy has not been established. Here, we report on a 58 year‐old man with type 1 diabetes mellitus, who developed progressive CA...
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Migraine is the most common neurological disease. Recently, there is a wide variety of prophylactic drugs, but their effects differ among individuals.
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Complications of levodopa–carbidopa intestinal gel (LCIG) therapy are relatively common, presenting in 40–96% of patients. Here, we report an unusual, accidental tube breakage in a patient with Parkinson’s disease (PD) under LCIG therapy. An 80-year-old man of PD with mild cognit...
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Inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD) is an autosomal dominant disorder caused by mutations in the valosin‐containing protein (VCP) gene. IBMPFD usually presents progressive limb muscle weakness resulting in wheelchaired after m...
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A 23-year-old man presented with weakness of shoulder abduction and elbow flexion on the right side, with numbness of the index finger and thumb, after a bike accident. On examination, he had grade II/V power of the deltoid and biceps, with absent biceps jerk and sensory impairme...
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Background: We treat non-parkinsonian motor disorders by thalamotomy, assuming their pathophysiological similarity to Parkinson's disease (PD).Aim: We compared the non-parkinsonian and parkinsonian brain activities to clarify their similarity and difference.Methods: We examined p...
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A 78‐year‐old man with atrial fibrillation treated with warfarin experienced acute headache, deafness, cerebellar ataxia and dysuria. Superficial siderosis was diagnosed on brain imaging; however, no bleeding sources were detected. His neurological deficits and bloody cerebrospin...
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Tumefactive demyelination is sometimes difficult differentiate from malignant tumors. Positron emission tomography with C-11-methionine is useful for diagnosing cerebral malignant tumors, but there are previous reports for tumefactive demyelination. We experienced a 32-year-old m...
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Transient myoclonic state with asterixis is characterized by sudden onset generalized myoclonus and asterixis without consciousness impairment. Electrophysiological studies have shown that myoclonus correlates with cortical hyperexcitability localized in the primary motor cortex ...
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