Alexander Kaplun

Alexander P. KAPLUN Date of birth: April 28, 1948 Citizenship: Russia Russia, Moscow Tel.: +7 916 374 3362 E-mail: alex.kaplun@mail.ru Sex: Male Place of birth: Moscow, Russia Marital status: married/child EDUCATION and RESEARCH EXPERIENCE 1975-1992 M.V. Lomonosov Moscow State Academy of Fine Chemical Technology (Moscow, Russia), Dep. of Biotechnology. Professor (1995) March-October 1995 Working as invited professor in Korea (Brain Pool Project of Korean government) 1990 D.Sc. (Chem.) - "Methods of synthesis of polar lipids modified in the hydrophobic region". M.V.Lomonosov Institute of Fine Chemical Technology, Dep. of Biotechnology 1984-1992 Assistant professor. M.V.Lomonosov Institute of Fine Chemical Technology Autumn, 1984, Internship at All-Union Scientific Research Institute "Genetics (genetic engineering laboratory) Autumn, 1978 Internship at the pharmacological factory "Biolek" 1977-1984 Assistant professor . M.V.Lomonosov Institute of Fine Chemical Technology. Department of Biologically Active and Natural Compounds 1975-1977 Junior researcher. M.V.Lomonosov Institute of Fine Chemical Technology, Department of Biologically Active and Natural Compounds 1975 Ph.D. - "Study on the synthesis of glycosyldiglycerides". M.V.Lomonosov Institute of Fine Chemical Technology, Department of Biologically Active and Natural Compounds 1972-1975 Post-graduate student, M.V.Lomonosov Institute of Fine Chemical Technology. Department of Biologically Active and Natural Compounds 1972 M.Sc. – “Study of methods of phosphorylation for lipids preparation” M.V.Lomonosov Institute of Fine Chemical Technology, Department of Biologically Active and Natural Compounds 1966-1972 Student, M.V.Lomonosov Institute of Fine Chemical Technology Teaching Lectures 1) "Biological membranes: structure, property and methods of study" at 1981-1983; 2) "Methods of the obtaining and isolation of biologically active compound (microbiological synthesis, genetic, and cell engineering)" at 1983-1985; 3) "General microbiology and the principles of biotechnology" at 1986-1992; 4) “Biotechnology of proteins" at 1990-1995; 5) “Molecular basic of biotechnology” from 1992; 6) “Drug Design and Drug Delivery Systems” from 1996. 7) Organic chemistry from 2014 8) Сonformational analysis 9) Bionanotechnology 10) Biotechnological methods for obtaining pharmaceuticals Managements M.S. Students - more then 100 Ph. D. Students - 18 Scientific activity of my laboratory: 1. Liposomal drug delivery systems 2. Nanoparticle drug delivery systems 3. Molecular modifications of betulinic acid as antineoplastic substances 4. Design of preparation for modulation of complement activation Grants: Grant of International Science & Technology Center (ISTC) # 1781 “Design and synthesis of new anti-virus and anti-tumor agents based on stable addressed liposomes carrying lipophilic drug derivatives” (2002-2004), Group Leader Grants of Russian Fund of Basic Research: • 00-04-48363 Effect of molecular modification of betulinic acid and its entrapping into liposomes on anticancer activity and an ability of mitochondrion to induce the apoptosis cascade (2000-2002) Team Leader • 00-04-4940 Liposomal models of polyvalent antigens: dependence of kinetic and equilibrium parameters of reaction with antibodies from structure of liposomes and diffusive properties of membranes (2000-2002) Group Leader • 98-04-48953 Study of inhibition mechanism of complement-induces haemolysis by high molecular complexes. (1998-2000) Group Leader • 97-04-49963 Study of mechanisms of action of liposomal formulations with DOPA/dopamine at experimental Parkinson syndrome (1997-1999) Group Leader State contract # I-0707 "Development of new methodology and products for the biotechnological industry, medicine and an agriculture" (2003-2004) Group Leader Grants of Ministry of Education: Each year my laboratory has 1-2 grants. Awards The winner of the competition of the Russian Fund of Basic Research for the best popular scientific work, 1999 Soros Professor' scholarship from Soros International Scientific Foundation, 2001 Soros Teacher' scholarship from Soros International Scientific Foundation, 2003