A Conserved Tryptophan in the Acylated Segment of RTX Toxins Controls Their Β2 Integrin–independent Cell Penetration

Adriana Osickova,Sarka Knoblochova,Ladislav Bumba,Petr Man,Zuzana Kalaninova,Anna Lepesheva,David Jurnecka,Monika Cizkova,Lada Biedermannova,Jory A. Goldsmith,Jennifer A. Maynard,Jason S. Mclellan,Radim Osicka,Peter Sebo,Jiri Masin

JOURNAL OF BIOLOGICAL CHEMISTRY（2023）

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RTX toxin,adenylate cyclase toxin,α-hemolysin,β2 integrins,acylated segment,tryptophan residue,thermal stability,hydrogen/deuterium exchange,cytotoxicity

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