Structure-based Development of Potent and Selective Type-Ii Kinase Inhibitors of RIPK1

Ying Qin,Dekang Li,Chunting Qi,Huaijiang Xiang,Huyan Meng,Jingli Liu,Shaoqing Zhou,Xinyu Gong,Ying Li, Guifang Xu,Rui Zu,Hang Xie,Yechun Xu, Gang Xu,Zheng Zhang, Shi Chen,Lifeng Pan,Li Tan

ACTA PHARMACEUTICA SINICA B（2024）

Cited 2|Views58

Key words

RIPK1,Necroptosis,Type-II kinase inhibitors,Rational design,Lead optimization,Structure-activity relationship,Anti-inflammation,Preclinical drug discovery

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